Skip to main content
. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Alcohol Clin Exp Res. 2016 May 5;40(6):1251–1261. doi: 10.1111/acer.13060

Figure 3.

Figure 3

Bidirectional changes in NMDA receptors and Kv4.2 channels are associated with similar changes in mRNA binding to FMRP. FMRP was immunoprecipitated from homogenates of hippocampal tissue obtained from control and chronic ethanol (75 mM) exposed hippocampal slice cultures. RT-qPCR analysis of the mRNA transcripts in the immunoprecipitate revealed a significant reduction in GluN2B mRNA in CIE exposed slice cultures. In contrast, there was a significant increase in the amount of Kv4.2 and KChIP3 mRNA (n = 7-8). Data represent mean ± SEM, * p < 0.05.