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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Alcohol Clin Exp Res. 2016 May 5;40(6):1251–1261. doi: 10.1111/acer.13060

Figure 5.

Figure 5

Inhibition of S6K1 prevents ethanol-induced changes in protein expression. Hippocampal slice cultures were chronically exposed to ethanol in the presence and absence of the S6K1 inhibitor PF-470861 (PF, 6 μM). Immunoblot analysis revealed that while PF had no effect on the expression of any of the proteins examined (A-D), it completely prevented the increase in expression of GluN1 (A) and GluN2B (B), and the reduction in expression of Kv4.2 (C) and KChiP3 (D) induced by chronic ethanol exposure (n = 7-8). Data represent mean ± SEM, * p < 0.05, ** p < 0.01.