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. 2016 Mar 3;68(1):33–40. doi: 10.1097/FJC.0000000000000379

FIGURE 2.

FIGURE 2.

Separate and combined effects of EPA and atorvastatin (active) metabolite (ATM) on human sdLDL (A), LDL (B), and VLDL (C) oxidation. EPA was tested at 1.0 μM. Data were collected after 1 hour (sdLDL and LDL) and 4 hours (VLDL) exposure to oxidative conditions. Values are mean ± SD (N = 3) and are expressed as molar equivalents of MDA. *P < 0.01 and †P < 0.001 versus vehicle-treated control; ‡P < 0.05 and §P < 0.001 versus EPA; ‖P < 0.05 and ¶P < 0.001 versus 0.5 μM atorvastatin metabolite; #P < 0.001 versus 1.0 μM atorvastatin metabolite; **P < 0.001 versus EPA + 0.5 μM atorvastatin metabolite (Student–Newman–Keuls multiple comparisons test; overall ANOVA—sdLDL data: P < 0.0001, F = 118.22; LDL data: P < 0.0001, F = 142.74; VLDL data: P < 0.0001, F = 52.613). ANOVA, analysis of variance; MDA, malondialdehyde.