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Irisin increased the number of Sca-1+Flk-1+ EPCs in DM mice. In DM mice, the number of Sca-1+Flk-1+ EPCs in peripheral blood was reduced significantly compared with NC mice. Treatment with irisin increased the number of Sca-1+Flk-1+ EPCs significantly in DM mice. *P < 0.05 versus NC group, **P < 0.05 versus DM group (n = 6 in each group).
