Figure 3. Temporal trends in individual serum lipid fractions in ICH patients by APOE allele carrier status.

(A–D) Loess smoothed curves of serum lipid levels (mg/dL) against time (in months) before and after ICH. Gray areas indicate standard error (SE). Time period of interest is indicated by shaded boxes (P₂ 0–6 months pre-ICH). *p < 0.0125, rate of change of serum lipids by Wald test for time period P₂ in APOE ε2 or ε4 carrier status compared with reference (APOE ε3/ε3). ICH = intracerebral hemorrhage.