Figure 5.

The primary challenge following gene identification remains understanding the pathobiological process; typically this problem has been tackled using limited scale and reductionist methods, which require some a priori hypotheses regarding potential mechanism of action. We suggest here that this understanding can be greatly facilitated using burgeoning high content screening technologies and large-scale data mining. Not only does this have the ability to implicate specific processes in disease, but it can also aid in further mapping of the genetic basis of disease.