Table 2.
The main results of the meta-analysis.
| Study group | Sample size (case/control) | Allelic model (d allele vs. D allele) |
Additive model (dd vs. DD) |
Additive model (Dd vs. DD) |
Dominant model (dd + Dd vs. DD) |
Recessive model (dd vs. Dd + DD) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR [95%CI] | p | OR [95%CI] | p | OR [95%CI] | p | OR [95%CI] | p | OR [95%CI] | p | ||
| Overall analysis | |||||||||||
| 137G/C | 1566/1372 | 0.91[0.66.1.25] | 0.55 | 0.79[0.50.1.27] | 0.33 | 0.92[0.64.1.32] | 0.64 | 0.91[0.63.1.31] | 0.61 | 0.78[0.49.1.24] | 0.29 |
| 607C/A | 1391/1194 | 0.73[0.65.0.81] | < 0.01 | 0.51[0.40.0.64] | < 0.01 | 0.68[0.56.0.82] | < 0.01 | 0.62[0.52.0.74] | < 0.01 | 0.67[0.55.0.80] | < 0.01 |
| Subgroup analysis based on types of ischemic stroke | |||||||||||
| 137G/C (LAA) | 267/602 | 0.55[0.40.0.77] | 0.01 | 0.20[0.05.0.85] | 0.03 | 0.56[0.28.1.11] | 0.10 | 0.53[0.30.0.94] | 0.03 | 0.22[0.05.0.94] | 0.04 |
| 137G/C (SVD) | 295/602 | 0.79[0.60.1.05] | 0.10 | 0.39[0.13.1.15] | 0.09 | 0.84[0.50.1.42] | 0.52 | 0.79[0.48.1.29] | 0.35 | 0.40[0.14.1.18] | 0.10 |
| 137G/C (CE) | 73/602 | 1.17[0.55.2.49] | 0.68 | 0.69[0.13.3.70] | 0.66 | 1.47[0.56.3.81] | 0.43 | 1.34[0.52.3.45] | 0.54 | 0.58[0.11.3.11] | 0.53 |
| 607C/A (LAA) | 183/384 | 0.52[0.40.0.67] | < 0.01 | 0.27[0.16.0.47] | < 0.01 | 0.41[0.27.0.61] | < 0.01 | 0.37[0.25.0.54] | < 0.01 | 0.50[0.31.0.80] | < 0.01 |
| 607C/A (SVD) | 189/384 | 0.87[0.68.1.11] | 0.26 | 0.20[0.12.0.32] | < 0.01 | 1.41[0.89.2.20] | 0.15 | 1.18[0.76.1.83] | 0.47 | 0.54[0.34.0.86] | < 0.01 |
| 607C/A (CE) | 51/384 | 1.32[0.87.2.01] | 0.19 | 0.73[0.37.1.44] | 0.36 | 0.86[0.39.1.90] | 0.71 | 1.10[0.53.2.28] | 0.81 | 1.78[0.97.3.29] | 0.06 |
| Subgroup analysis based on age of subjects | |||||||||||
| 137G/C (~ 65) | 160/154 | 1.15[0.73.1.79] | 0.55 | 0.34[0.04.3.34] | 0.36 | 1.34[0.81.2.22] | 0.26 | 1.26[0.77.2.08] | 0.36 | 0.32[0.03.3.08] | 0.32 |
| 137G/C (65 ~) | 263/230 | 0.71[0.50,102 | 0.06 | 0.30[0.09.0.95] | 0.04 | 0.86[0.56.1.31] | 0.49 | 0.77[0.51.1.15] | 0.20 | 0.31[0.10.0.98] | 0.05 |
| 607C/A (~ 65) | 319/317 | 0.57[0.45.0.71] | < 0.01 | 0.36[0.22.0.58] | < 0.01 | 0.50[0.35.0.72] | < 0.01 | 0.46[0.33.0.64] | < 0.01 | 0.49[0.32.0.77] | < 0.01 |
| 607C/A (65 ~) | 227/201 | 0.89[0.68.1.18] | 0.42 | 0.77[0.38.1.56] | 0.47 | 0.93[0.48.1.81] | 0.83 | 0.87[0.46.1.67] | 0.68 | 0.82[0.54.1.24] | 0.35 |
| Subgroup analysis based on gender of subjects | |||||||||||
| 137G/C (Male) | 256/231 | 0.76[053.1.09] | 0.14 | 0.10[0.01.0.77] | 0.03 | 0.98[0.64.1.49] | 0.92 | 0.85[0.57.1.28] | 0.44 | 0.10[0.01.0.77] | 0.03 |
| 137G/C (Female) | 167/153 | 1.02[0.66.1.56] | 0.94 | 0.75[0.20.2.85] | 0.67 | 1.11[0.67.1.84] | 0.69 | 1.07[0.65.1.74] | 0.80 | 0.73[0.19.2.76] | 0.64 |
| 607C/A (Male) | 526/464 | 0.65[0.55.0.78] | < 0.01 | 0.39[0.27.0.58] | < 0.01 | 0.75[0.56.1.01] | 0.05 | 0.63[0.48.0.84] | < 0.01 | 0.46[0.33.0.64] | < 0.01 |
| 607C/A (Female) | 116/131 | 0.97[0.67.1.40] | 0.87 | 0.72[0.33.1.59] | 0.42 | 0.52[0.24.1.15] | 0.10 | 0.61[0.29.1.28] | 0.19 | 1.19[0.72.1.98] | 0.50 |
| Sensitivity analysis | |||||||||||
| 137G/C (High quality) | 1413/1258 | 0.82[0.61.1.11] | 0.20 | 0.78[0.40.1.13] | 0.13 | 0.82[0.58.1.16] | 0.26 | 0.81[0.57.1.14] | 0.23 | 0.69[0.41.1.15] | 0.15 |
| 607C/A (HWE pH > 0.05) | 1198/1074 | 0.74[0.66.0.83] | < 0.01 | 0.53[0.42.0.68] | < 0.01 | 0.72[0.58.0.88] | < 0.01 | 0.66[0.54.0.79] | < 0.01 | 0.67[0.55.0.82] | < 0.01 |
d was for the mutant allele and D was for the common allele; OR, odds ratio; CI, confidence intervals; p, a p-value of the test; LAA, large artery atherosclerosis; SVD, small vessel disease; CE cardioembolism; High quality, NOS (Newcastle Ottawa Scale) score > 7; HWE, Hardy-Weinberg equilibrium.