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Tau mislocalization in disease conditions. In Alzheimer’s disease (Human AD) and transgenic rat model expressing human truncated tau protein aa151-391 (Transgenic rat model) tau protein is mislocalized to the postsynaptic fraction (Post). Synaptic fractions were isolated as previously reported [78]. Recombinant 6 human tau isoforms (6i) and truncated 3 repeat tau protein (3R) were used as controls.
