Figure 3.

Adjusted hazard ratios (HRs) for clinical end points associated with biomarker quartiles. Quartile cut points were defined differently for each study, as described in Supplementary Table 2. HRs were adjusted for factors included in model 2, namely demographic characteristics (age, sex, race, and body mass index [calculated as the weight in kilograms divided by the height in meters squared]), antiretroviral therapy use, nadir and baseline CD4⁺ T-cell counts, baseline human immunodeficiency virus RNA level, prior AIDS and cardiovascular disease, diabetes mellitus, and hepatitis B virus and hepatitis C virus coinfection. HRs calculated as in models 1 and 3 showed consistent results (data not shown). Abbreviations: CI, confidence interval; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin 6.