Table 1.
Baseline Characteristics Participants in the Control Arms of SMART and ESPRIT
| Characteristic | Overall (n = 4304) | All-Cause Death (n = 157) | Non–AIDS-Related, Nonviolent, Unintentional Death (n = 117) | AIDS (n = 101) | CVD (n = 121) | Non–AIDS-Defining Malignancy (n = 99) |
|---|---|---|---|---|---|---|
| Age, y | 42 [36, 49] | 48 [40, 54] | 48 [41, 55] | 44 [38, 50] | 49 [43, 56] | 50 [44, 57] |
| Female sex | 1002 (23.3) | 28 (17.8) | 17 (14.5) | 22 (21.8) | 14 (11.6) | 14 (14.1) |
| Black race | 907 (21.1) | 29 (18.5) | 25 (21.4) | 18 (17.8) | 26 (21.5) | 26 (26.3) |
| BMIa | 24.4 [22.1, 27.1] | 23.5 [21.4, 27.3] | 23.3 [21.3, 27.1] | 25.2 [22.6, 29.0] | 24.0 [22.1, 27.4] | 23.9 [21.7, 25.8] |
| Prior AIDS | 1093 (25.4) | 46 (29.3) | 32 (27.4) | 42 (41.6) | 47 (38.8) | 21 (21.2) |
| Hepatitis B/C | 761 (17.7) | 54 (34.4) | 41 (35.0) | 16 (15.8) | 18 (14.9) | 27 (27.3) |
| Prior CVD | 112 (2.6) | 14 (9.0) | 12 (10.3) | 1 (1.0) | 16 (13.3) | 5 (5.1) |
| Diabetes | 217 (5.1) | 14 (9.0) | 10 (8.6) | 7 (6.9) | 14 (11.7) | 9 (9.1) |
| PI-based ART | 1478 (34.3) | 53 (33.8) | 45 (38.5) | 31 (30.7) | 52 (43.0) | 41 (41.4) |
| NNRTI-based ART | 1643 (38.2) | 52 (33.1) | 39 (33.3) | 34 (33.7) | 30 (24.8) | 30 (30.3) |
| CD4+ T-cell count, cells/mm3 | ||||||
| Baseline | 526 [415, 701] | 451 [370, 594] | 470 [384, 639] | 466 [376, 599] | 515 [401, 673] | 526 [404, 679] |
| Nadir | 230 [120, 337] | 194 [93, 297] | 194 [85, 282] | 190 [90, 298] | 187 [74, 301] | 219 [97, 311] |
| HIV RNA load ≤500 copies/mL | 3263 (75.8) | 97 (61.8) | 77 (65.8) | 51 (50.5) | 88 (72.7) | 75 (75.8) |
| IL-6, pg/mL | 1.80 [1.18, 2.90] | 3.09 [2.10, 4.40] | 3.17 [2.10, 4.49] | 2.42 [1.40, 3.33] | 2.60 [1.78, 4.30] | 2.50 [1.81, 3.58] |
| hsCRP, µg/mL | 1.60 [0.69, 3.67] | 2.83 [1.53, 6.27] | 2.70 [1.57, 6.18] | 2.03 [0.83, 4.50] | 2.33 [1.02, 5.05] | 2.54 [1.13, 4.93] |
| D-dimer, µg/mL | 0.24 [0.15, 0.38] | 0.33 [0.23, 0.55] | 0.35 [0.23, 0.55] | 0.31 [0.22, 0.53] | 0.31 [0.20, 0.51] | 0.28 [0.18, 0.52] |
Data are no. (%) of subjects or median value (interquartile range).
Abbreviations: ART, antiretroviral therapy; CVD, cardiovascular disease; HIV, human immunodeficiency virus; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin 6; NNRTI, nonnucleoside reverse transcriptase inhibitor; PI, protease inhibitor.
a Body mass index (BMI) is calculated as the weight in kilograms divided by the height in meters squared.