Fig 2. Definition of continuous administration, co-administration, and observation period for statins and warfarin.

(A) Continuous administration was defined as repeated prescriptions of the same medication with a <30-day interval between the end of the previous prescription and start of the following prescription. The co-administration period was defined as overlapping continuous administration of both a statin and warfarin. (B) The observation period lasted up to 2 years from the start of the statin and warfarin co-administration and ended when a gastrointestinal (GI) bleeding event occurred or observation was censored.