Table 4. Survival prediction: summary of class performance and hazard ratios for associations between imaging features and overall survivala.
| Variable | ROC analysis | Cox regression model | ||||||
|---|---|---|---|---|---|---|---|---|
| Cutoff | AUC | Sensitivity | Specificity | PPV | NPV | Hazard ratio (95% CI) | p-value | |
| Univariate Analysis | ||||||||
| fCER (%) | 9.860 | 0.893 (0.723–1.063) | 1.000 | 0.714 | 1.000 | 0.800 | 1.193 (0.941–1.513) | 0.145 |
| D*CER (x10-3mm2/s) | 21.712 | 0.857 (0.648–1.067) | 1.000 | 0.714 | 0.800 | 1.000 | 1.000 (1.000–1.000) | 0.068 |
| rCBFCER (ml/100g/min) | 59.010 | 0.821 (0.593–1.050) | 0.625 | 1.000 | 1.000 | 0.700 | 1.025 (0.9934–1.057) | 0.123 |
| rCBVCER (ml/100g) | 4.780 | 0.821 (0.599–1.044) | 0.750 | 0.857 | 0.857 | 0.750 | 1.158 (0.7698–1.742) | 0.481 |
| max rCBFCER (ml/100g/min) | 155.25 | 0.786 (0.533–1.000) | 0.750 | 0.857 | 0.857 | 0.750 | 1.032 (0.995–1.069) | 0.089 |
| max rCBVCER (ml/100g) | 10.765 | 0.821 (0.598–1.000) | 0.875 | 0.714 | 0.750 | 0.714 | 1.044 (0.864–1.261) | 0.658 |
| Treatment | 1.500 | 0.723 (0.490–0.956) | 0.857 | 0.571 | 0.700 | 0.800 | 5.484 (1.162–25.88) | 0.031 |
| Multivariate Analysis | ||||||||
| fCER and treatment | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | |||
| D*CER and treatment | 0.929 | 1.000 | 0.857 | 0.889 | 1.000 | |||
| rCBFCER and treatment | 0.929 | 0.875 | 0.857 | 0.875 | 0.857 | |||
| rCBVCER and treatment | 0.893 | 1.000 | 0.750 | 0.778 | 1.000 | |||
aData are hazard ratio estimates, with 95% confidence intervals in parentheses, for variables included in the Cox regression model (imaging features plus clinical variables) for the analysis of the association between the imaging features and overall survival after adjusting for standard clinical variables. Likelihood ratio test of this model versus the null model: P = 0.047 (test statistic = 15.66 with eight degrees of freedom).