Table 2. Human genes most significantly repressed by IE1 1 .
| Probe Set ID | Gene Symbol | 24 h post induction 2 | 72 h post induction 3 | STAT3-responsive 4 | ||
|---|---|---|---|---|---|---|
| IE1+/TetR+ | IE1+/IE1- | IE1+/TetR+ | IE1+/IE1- | |||
| 8077270 | CHL1 | -2.8 | -1.5 | -5.5 | -2.8 | Fig 2 |
| 8005048 | MYOCD | -3.9 | -1.7 | -4.2 | -1.9 | S1 Fig |
| 8141094 | PDK4 | -3.8 | -1.3 | -3.5 | -1.4 | S1 Fig |
| 8156706 | TMOD1 | -1.9 | -1.5 | -3.3 | -2.6 | S1 Fig |
| 7929511 | ENTPD1 | -2.5 | -1.2 | -3.1 | -1.5 | [180] |
| 8018864 | SOCS3 | -2.8 | -2.1 | -3.0 | -2.5 | Fig 2 |
| 8095585 | SLC4A4 | -1.7 | -1.2 | -3.0 | -2.1 | [180] |
| 8077366 | LRRN1 | -2.1 | 1.1 | -3.0 | -1.1 | S1 Fig |
| 8062461 | LBP | -2.1 | -1.2 | -2.9 | -1.5 | [180] |
| 7925929 | AKR1C3 | -2.4 | -1.6 | -2.8 | -2.2 | S1 Fig |
| 7921916 | RGS5 | -2.8 | -1.1 | -2.8 | 1.0 | S1 Fig |
| 8178712 | TNXB | -1.6 | -1.2 | -2.7 | -2.0 | [82] |
| 8179935 | TNXB | -1.6 | -1.2 | -2.7 | -2.0 | [82] |
| 8092169 | TNFSF10 | -3.1 | -1.2 | -2.7 | 1.0 | [81] |
| 8149825 | STC1 | -2.0 | 1.0 | -2.7 | -1.5 | — 5 |
| 8166632 | GK | -2.4 | -1.7 | -2.6 | -1.7 | [81] |
| 8101788 | UNC5C | -2.4 | -1.1 | -2.6 | -1.4 | [180] |
| 8174103 | GK | -2.4 | -1.7 | -2.5 | -1.7 | [81] |
| 7923547 | CHI3L1 | -1.1 | -1.2 | -2.5 | -2.4 | [134] |
| 7898057 | PDPN | -2.2 | 1.0 | -2.5 | -1.1 | [180] |
| 7968236 | RASL11A | -2.1 | -1.6 | -2.4 | -2.2 | Fig 2 |
| 8100109 | GABRA2 | -2.6 | -1.2 | -2.4 | -1.1 | [180] |
| 8118409 | C4A | -1.4 | -1.2 | -2.4 | -2.2 | Fig 2 |
| 8118455 | C4A | -1.4 | -1.2 | -2.4 | -2.2 | Fig 2 |
| 8179399 | C4A | -1.4 | -1.2 | -2.4 | -2.2 | Fig 2 |
| 7972157 | EDNRB | -3.3 | -1.2 | -2.4 | 1.0 | S1 Fig |
| 8063437 | TSHZ2 | -2.5 | -1.3 | -2.3 | -1.3 | [180] |
| 8057486 | PDE1A | -1.3 | -1.3 | -2.3 | -2.3 | S1 Fig |
| 7918857 | TSPAN2 | -3.2 | 1.0 | -2.3 | 1.5 | S1 Fig |
| 8056376 | SCN3A | -1.2 | -1.6 | -2.2 | -2.7 | [180] |
| 8063444 | TSHZ2 | -2.6 | -1.3 | -2.2 | -1.2 | [180] |
| 8064868 | GPCPD1 | -2.7 | -1.1 | -2.2 | -1.2 | S1 Fig |
| 8045539 | KYNU | -2.6 | -1.2 | -2.2 | -1.1 | [81] |
| 7933194 | CXCL12 | -1.2 | -1.2 | -2.2 | -2.2 | Fig 2 |
| 7908376 | RGS18 | -3.6 | -1.3 | -2.2 | 1.0 | S1 Fig |
| 7902527 | PTGFR | -1.7 | -1.6 | -2.1 | -2.1 | — 5 , 6 |
| 8166925 | MAOA | -2.8 | -1.2 | -2.1 | 1.0 | [180] |
| 8151942 | HRSP12 | -1.3 | -1.3 | -2.0 | -2.0 | S1 Fig |
| 7985032 | (LOC391532) 7 | -2.2 | -2.6 | 1.4 | -1.2 | ND |
| 7906400 | IFI16 | -1.3 | -1.4 | -1.7 | -1.8 | Fig 2 |
1 ≥2.0-fold average decrease in at least one or ≥1.5-fold average decrease in at least two of the following four comparisons: dox-treated TetR-IE1 (TetR-IE1+) vs. dox-treated TetR (TetR+) cells 24 h post induction, TetR-IE1+ vs. TetR+ cells 72 h post induction, TetR-IE1+ vs. solvent-treated TetR-IE1 (TetR-IE1-) cells 24 h post induction or TetR-IE1+ vs. TetR-IE1- cells 72 h post induction; and ≤1.5-fold average decrease in comparisons of TetR+ vs. TetR cells 24 h or 72 h post induction. Symbols of genes further investigated in this work are bold-typed. IFI16 was further investigated despite narrowly missing the criteria outlined above.
2 maximum average fold change in comparisons of TetR-IE1+ vs. TetR+ or TetR-IE1+ vs. TetR-IE1- cells 24 h post induction.
3 maximum average fold change in comparisons of TetR-IE1+ vs. TetR+ or TetR-IE1+ vs. TetR-IE1- cells 72 h post induction.
4 known target of STAT3 up-regulation or/and binding based on provided reference or this work (Fig 2, S1 Fig); ND, not determined.
5 not significantly STAT3-responsive according to S1 Fig.
6 IL6-responsive according to Table 1.
7 long non-coding RNA.