Fig. 1.
Effects of prophylactic administration of extracts of Plantaginis Semen (EPS) and Achyranthis Radix (EAR) on paclitaxel (PTX)-induced mechanical allodynia. (A) Development of mechanical allodynia after a single injection of PTX. (B) Effects of EPS on PTX-induced allodynia. (C) Effects of EAR on PTX-induced allodynia. PTX (5 mg/kg) and its vehicle (VH1) were injected intraperitoneally in mice. EPS, EAR, and their vehicle (VH2) were administered orally once daily from the day after PTX injection. Data are presented as the mean and standard error of the mean (n = 5–6). *p < 0.05 compared to VH1 (Mann–Whitney test) or VH2 (Dunn's multiple comparisons with the control).