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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: ACS Chem Neurosci. 2015 Mar 30;6(6):927–935. doi: 10.1021/acschemneuro.5b00078

Figure 4.

Figure 4

Ligand in vivo activity. (A) EEG recording 1.75–2.4 min after injection of 200 mg/kg fropofol. Phenotypical seizure activity observed within frontal association (FrA), primary motor (M1), medial parietal association area (MPAA), primary somatosensory (S1), and primary auditory (A1) traces. Postictal state (PI) was observed after seizing activity. (B) Propofol dose–response curves with the coadministration of 0 μM (black circles), 5 μM (violet triangles), 25 μM (green squares), and 100 μM (red diamonds) of fropofol within X. laevis tadpoles. Immobility was measured as loss of spontaneous movement.