Table 5.
Major toxicities during dCRT
| Adverse reaction | Group A (%) | Group B (%) | P-value |
|---|---|---|---|
| Toxicities (CTCAE 4.0) | |||
| Overall toxicity ≥ grade 3 | 24 (22.9) | 35 (36.5) | 0.039 |
| Grade 3 | 17 (16.2) | 25 (25.8) | 0.094 |
| Grade 4 | 7 (6.7) | 10 (10.3) | 0.352 |
| Hematological ≥ grade 3 | 11 (10.5) | 16 (16.5) | 0.209 |
| Nonhematological ≥ grade 3 | 13 (12.4) | 19 (19.6) | 0.161 |
| Hematological | |||
| Neutropenia | |||
| Grade 3 | 4 (3.8) | 9 (9.2) | 0.118 |
| Grade 4 | 2 (1.9) | 3 (3.1) | 0.587 |
| Thrombocytopenia | |||
| Grade 3 | 5 (4.8) | 4 (4.1) | 1.000 |
| Grade 4 | 3 (2.9) | 4 (4.1) | 0.712 |
| Anemia | |||
| Grade 3 | 1 (1.0) | 5 (5.2) | 0.107 |
| Grade 4 | 0 (0) | 1 (1.0) | 0.480 |
| Nonhematological | |||
| Nausea/vomiting | 6 (5.7) | 7 (7.2) | 0.664 |
| Diarrhea | 3 (2.9) | 2 (2.1) | 1.000 |
| Esophagitis | 0 (0.0) | 1 (1.0) | 0.480 |
| Pneumonia | 1 (1.0) | 0 (0.0) | 1.000 |
| Other | 3 (2.9) | 9 (9.3) | 0.054 |
Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; dCRT, definitive concurrent chemoradiotherapy.