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Implications of mechanisms of enhancer selection and function for interpretation of genome-wide association studies (GWAS). Panel A. Schematic overview illustrating how SNPs identified in GWAS and associated with expression quantitative trait loci (eQTL) can affect enhancers in a cell-type specific manner. Panel B. Schematic overview how studies identifying disease-associated genomic variations in mouse can be helpful in understanding human disease through conserved sequence.
