Samples of different uses of silk, natural and biomedical ones. Images show a spider web (photo courtesy Francesco Tomasinelli and Emanuele Biggi), silk cocoons, silk-based electronics (Reprinted by permission from ref 17. Copyright 2010 Macmillan Publishers.) and the “Silk Pavilion” (Designed by the Mediated Matter Group in collaboration with James Weaver, WYSS Institute, Harvard University and Prof. Fiorenzo Omenetto, TUFT University. Contributing researchers: Markus Kayser, Jared Laucks, Carlos David Gonzalez Uribe, Jorge Duro-Royo and Steven Keating. Photo credit: Steven Keating. Courtesy of Mediated Matter). These examples showcase the versatility of silk in its natural and synthetic uses.