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. Author manuscript; available in PMC: 2016 Jul 7.
Published in final edited form as: Anesthesiology. 2013 Oct;119(4):901–906. doi: 10.1097/ALN.0b013e3182a2a38c

Fig. 1.

Fig. 1

Survival analyses—volatile anesthetics. (A) Conditioning with volatile anesthetics. Survival was assessed over 7 days in a cecal ligation and puncture (CLP) model with a >75% mortality at postoperative day 3 and overall survival of 17% observed in the CLP group. Exposure (1.2 MAC for 2 h) to anesthetic concentrations of desflurane and sevoflurane significantly improved overall survival in CLP mice to 58% (P = 0.049) and 83% (P < 0.001), respectively. Equi-MAC concentrations of isoflurane were less effective (P = 0.12). (B) Postconditioning with volatile anesthetics. Sevoflurane but not desflurane postconditioning (1 MAC for 0.5 h) 24 h after CLP procedure markedly improved overall survival of 66% no mortality after postoperative day 2 (P = 0.045). DES = desflurane; ISO = isoflurane; MAC = minimal alveolar concentration; Postcond = postconditioning; SEVO = sevoflurane. *P < 0.05.