Renal (A) and hepatic (B) function in SHAM, cecal ligation and puncture (CLP), and sevoflurane coconditioning groups. Assessing renal injury markers, a CLP-induced increase in blood urea nitrogen (BUN) was found. Hepatic markers (alkaline phosphatase [ALP]; alanine transaminase [ALT]; aspartate transaminase [AST]) were increased in the CLP group (N = 6) compared with the SHAM group (N = 3). Compared with the CLP group, application of sevoflurane (SEVO, 1.2 minimal alveolar concentration, 2 h, N = 6) in CLP animals efficiently reduced markers of organ damage to levels that were comparable with those in SHAM animals. Values are means ± SD. *P < 0.05. SEVO = sevoflurane.