Skip to main content
. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Mol Pharm. 2016 Jan 11;13(2):357–368. doi: 10.1021/acs.molpharmaceut.5b00542

Figure 7.

Figure 7

Lipid accumulation in LSD fibroblasts. (A) Fluorescence images of wild-type (Wt), NPD, NPC, Gaucher, and Fabry fibroblasts incubated overnight with fluorescent BODIPY-FL-C12-sphingomyelin or stained with filipin, in order to visualize sphingomyelin and cholesterol, respectively. Dashed lines = cell borders, as observed from phase-contrast microscopy. Scale bar = 10 μm. (B) Quantification of lipid accumulation, normalized to that of Wt cells (horizontal bar). Data are the mean ± SEM. *Comparison with Wt (p<0.05 by Student’s t-test).