Table 3.
Dn-collagen targeting molecules and their applications.
| Dn-collagen targeting molecules | Discovery method | Target | Kd (μM)* | Application | Ref. |
|---|---|---|---|---|---|
| mAb HUIV26 | Subtractive immunization | Thermally dn-collagen type IV | n.d. | Inhibit angiogenesis and tumor growth | 100–102 |
| mAb HUI77 | Subtractive immunization | Thermally dn-collagen type I–V | n.d. | 100–102 | |
| D93 | HUI77-derived humanized mAb | MMP-processed dn-collagen type IV | 6.5 | Inhibit tumor growth | 85 |
| mAb E1E5 | Quantitative immunoassay | Dn-collagen type II | n.d. | Detect dn-collagen type II | 105 |
| mAb E4A11 | Quantitative immunoassay | Dn-collagen type II | n.d. | Detect dn-collagen type II | 105 |
| TLTYTWS | Phage display | MMP2-processed collagen type IV | n.d. | Reduce endothelial differentiation and inhibit angiogenesis | 106 |
*
n.d. = not determined