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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2016 May 9;15(7):1485–1494. doi: 10.1158/1535-7163.MCT-15-0566

Figure 4. GS87 effectively modulates GSK3-dependent proteins.

Figure 4

(A) GS87-induced differentiation is independent of β-catenin. OCI cells with stable knockdown of β-catenin showed similar differentiation as compared to cells transfected with empty vector after treatment with GS87 for 3 days as measured by NBT reduction. (B-C) GS87 modulates GSK3 target proteins important in cell proliferation and differentiation more effectively than Li and SB. HL-60 cells were treated as indicated for 2 and 4 days (B) or 4 days (C) and assessed by western blot for key AML growth and differentiation proteins that can be modulated by GSK3.