Table 1.
List of upstream regulators related to MAPK signaling identified from pathway analysis of genes significantly modulated (>2 fold) after treatment with GS87 (30μM), Li (10mM) or SB (20μM) for 48 hours.
| MAPK pathway – GS87 | ||
|---|---|---|
| Upstream regulator | Activation Fold Change | p-value |
| SB203580 | −5.84 | 5.43E-13 |
| PD98059 | −5.231 | 7.30E-26 |
| U0126 | −4.754 | 5.18E-15 |
| SP600125 | −3.885 | 1.92E-09 |
| SB202190 | −3.024 | 1.36E-10 |
| MAPK10 | 2.197 | 1.37E-04 |
| MAPK | 2.287 | 6.33E-09 |
| MAP2K1/2 | 2.365 | 6.66E-09 |
| MAPK13 | 2.404 | 4.15E-04 |
| MAPK12 | 2.418 | 2.17E-04 |
| MAP3K7 | 2.494 | 1.23E-06 |
| MAP2K3 | 2.760 | 1.10E-05 |
| MAPK7 | 2.768 | 2.01E-05 |
| MAPK3 | 3.056 | 1.45E-06 |
| MAP2K1 | 3.092 | 4.83E-10 |
| MAPK14 | 3.429 | 8.35E-04 |
| MAP3K8 | 3.765 | 2.11E-06 |
| ERK1/2 | 3.805 | 8.31E-11 |
| ERK | 3.961 | 8.06E-17 |
| JNK | 3.966 | 7.79E-07 |
| MAPK pathway – SB | ||
|---|---|---|
| Upstream regulator | Activation Fold Change | p-value |
| U0126 | -2.949 | 9.97E-07 |
| LY294002 | -2.681 | 6.23E-05 |
| PD98059 | -2.662 | 2.13E-05 |
| SB203580 | -2.153 | 2.32E-04 |
| ERK | 2.000 | 1.70E-05 |
| MAPK pathway – Li | ||
|---|---|---|
| Upstream regulator | Activation Fold Change | p-value |
| JNK | 2.221 | 4.88E-03 |
| ERK | 2.592 | 3.47E-04 |