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. 2016 Jul 7;6:58. doi: 10.1186/s13550-016-0213-8

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — PET images, summed 30–60 min, and TACs from a Balbc nu/nu mouse (prone) bearing tumors (white arrows): a one A431 xenograft (1 × 10⁷ cells, 15 days) or b two A431 xenografts (left: 1 × 10⁷ cells, 28 days; right: 1 × 10⁷ cells, 25 days). Comparison A shows a 7-times higher uptake with targeting [methyl-¹¹C]-Z_EGFR:2377-ST-CH₃ compared to the non-targeting [methyl-¹¹C]-Z_Taq:3638-ST-CH₃. Comparison B illustrates uptake of the targeting Affibody increasing as the tumors grow from time from inoculation