Fig. 2.

Pathway diagram of the glycolysis pathway. Statistically significant genes (p < 0.01) (between critically ill and healthy controls) are coloured in either red or green. Red colour denotes up-regulation, and green colour denotes down-regulation. Lines with one-direction arrow (i.e. irreversible reaction) represent key regulatory control steps of the pathway. Lines with arrows on both directions denote reversible reactions determined by mass effect (i.e. forward and backward reaction can occur depending on substrate concentration)