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. 2016 Jul 7;4:21. doi: 10.1186/s40635-016-0094-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Pathway diagram of the genes in the tricarboxylic acid cycle. Statistically significant genes (p < 0.01) (between critically ill and healthy controls) are coloured in either red or green. Red colour denotes up-regulation, and green colour denotes down-regulation. Lines with one-direction arrow (i.e. irreversible reaction) represent key regulatory control steps of the pathway. Lines with arrows on both directions denote reversible reactions determined by mass effect (i.e. forward and backward reaction can occur depending on substrate concentration)