Table 4.

Estimated mean change in HRQOL, fatigue and physical activity from baseline to follow-up among patients with unimproved versus improved work status

	Changes within the improved group (N = 68)		Changes within the unimproved group (N = 38)
	Mean change	p value	Mean change	p value
EORTC QLQ-C30 functions (mean SD)
Physical functioning (PF)	8.5	<0.001	6.1	0.022
Role functioning (RF)	25.8	<0.001	17.6	<0.001
Emotional functioning (EF)	9.0	<0.001	5.4	0.06
Cognitive functioning (CF)	5.4	0.017	3.9	0.36
Social functioning (SF)	18.4	<0.001	8.8	0.09
Global health and quality of life (GQL)	14.1	<0.001	7.2	0.035
EORTC QLQ-C30 symptoms (mean SD)
Fatigue	−17.9	<0.001	−18.3	0.001
Nausea/vomiting	−2.7	0.040	−2.3	0.34
Pain	−9.7	0.003	1.3	0.79
Dyspnea	−14.9	<0.001	−7.2	0.15
Sleep problems	−11.6	0.002	− 0.9	0.87
Appetite loss	−9.0	0.002	−5.4	0.25
Constipation	−5.6	0.15	1.9	0.69
Diarrhea	−4.0	0.15	−1.9	0.76
Financial problems	1.5	0.58	10.8	0.012
Fatigue Questionnaire (mean SD)
Physical fatigue (P-Fat)	−3.1	<0.001	−3.3	<0.001
Mental fatigue (M-Fat)	−0.4	0.08	−0.2	0.48
Total fatigue (T-Fat)	−3.5	<0.001	−3.5	<0.001
Physical activity index	0.2	0.33	0.7	0.022

Italic: p values <0.05 were considered significant

EORTC QLQ-C30 European Organization for Research and Treatment Core Quality of Life Questionnaire-C30, SD standard deviation