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. 2016 Jul 7;5(1):990. doi: 10.1186/s40064-016-2390-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — The role of the immune system in promoting the symmetric and asymmetric division and differentiation of ovarian germ stem cells. a Uncommitted OGSCs(u-OGSCs) were produced in the first six weeks of pregnancy; b Primordial germ cells (PGC) were invaded OGSCs layerin the first seven weeks of pregnancy; c–e OGSCs only the joint action of cell signaling (cellular signaling, CS; as CD14 secreted by MDC and CD8 secreted by T lymphocytes) and hormonal signals (hormonal signaling, HS; chorionic gonadotropin, hCG and estradiol, E2) can occur secondary asymmetric division to produce germ cells, germ cells into secondary ovarian cortex and eventually differentiate into oocytes (definitive oocytes, DO).

Modified from Bukovsky and Caudle (2012)