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EBV-mediated activation of STAT3 in epithelial cells. STAT3 can be phosphorylated at Y705 by EBV LMP1 through the cooperation of cellular proteins such as NFκB, IL6, EGFR and Janus kinases. LMP1 can also cause phosphorylation of STAT3 at S727 through PKCδ. LMP2A can impair NFκB-mediated expression of IL6, thereby suppressing STAT3 activation.
