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Mechanisms of STAT3 activation in KSHV-infected B lymphocytes. STAT3 is phosphorylated by Janus kinases and KSHV IL6 (vIL6) in PEL cells. Activated STAT3 can transcriptionally activate the STAT3 gene while KSHV can repress cellular PDLIM2, an inhibitor of STAT3. KSHV LANA can serve as a transcriptional coactivator of STAT3. STAT3 represses KSHV lytic genes by transcriptional activation of the cellular corepressor KAP1.
