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. 2016 Jul 8;9:53. doi: 10.3389/fnmol.2016.00053

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Copyright © 2016 Cunnane, Courchesne-Loyer, Vandenberghe, St-Pierre, Fortier, Hennebelle, Croteau, Bocti, Fulop and Castellano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(Upper) Whole brain ¹⁸F-FDG uptake was 9% lower in mild AD (n = 12) compared to cognitively normal age-matched controls (Older; n = 42; #p < 0.05 corrected for false discovery rate). ¹⁸F-FDG uptake was also 9% lower in healthy older adults compared to younger adults (Young; n = 30; ^∗p < 0.05 corrected for false discovery rate). Values for mild cognitive impairment (MCI; n = 9) were not statistically different between the Older and AD groups. In contrast to FDG, whole brain ¹¹carbon-acetoacetate (¹¹C-AcAc) uptake did not differ significantly between any groups. (Lower) statistical differences were present for the ¹⁸F-FDG and ¹¹C-AcAc uptake constants (Nugent et al., 2014b; Castellano et al., 2015b).