Table 4.

DCIS characteristics according to different subtypes of IBC (n = 16014)

Characteristic	ER+, PR high, Her2− (n = 21315)		ER+, PR− or low Her2− (n = 7541)		ER+, Any PR, Her2+ (n = 2806)		ER−, PR−, Her2+ (n = 1334)		ER−, PR−, Her2− (n = 3941)		P-value
Presence of DCIS, no (%)											<0.0001
Yes	9168	43.01	3078	40.82	1658	59.09	766	57.42	1344	34.10
No	12,147	56.99	4463	59.18	1148	40.91	568	42.58	2597	65.90
DCIS grade, no (%)											<0.0001
1	1983	21.77	512	16.72	61	3.70	4	0.53	38	2.86
2	5310	58.32	1613	52.66	572	34.73	106	13.93	294	21.11
3	1813	19.91	938	30.62	1014	61.57	651	85.55	998	75.04
Missing	61	–	15	–	11	–	5	–	14	–
Presence of DCIS-associated microcalcifications, no (%)											<0.0001
Yes	2464	48.21	876	52.02	512	59.26	240	60.91	308	40.90
No	2647	51.79	808	47.98	352	40.74	154	39.09	445	59.10
Missing	4057	–	1394	–	794	–	372	–	591	–
DCIS restricted to invasive component, no (%)											<0.0001
Yes	2774	48.52	823	43.82	383	39.24	127	29.13	345	41.97
No	2943	51.48	1055	56.18	593	60.76	309	70.87	477	58.03
Missing	3451	–	1200	–	682	–	330	–	522	–
Diameter of DCIS, cm, mean, median and range	Mean: 1.9; Median: 1.4 Range: 0–20		Mean: 1.9; Median: 1.4 Range: 0–19		Mean: 2.6; Median: 2.0 Range: 0–20		Mean: 3.2; Median: 2.3 Range: 0–20		Mean: 2.1; Median: 1.5 Range: 0–15		<0.0001
Resection margin status of DCIS componenta
Free	5103	85.33	1622	83.44	707	78.82	251	71.10	640	82.79	<0.0001
Focally  irradical	640	10.70	245	12.60	127	14.16	73	20.68	83	10.74
More than  focally  irradical	237	3.96	77	3.96	63	7.02	29	8.22	50	6.47
Missing	22	–	5	–	2	–	0	–	5	–

^aAnalysis restricted to patients with BCS and presence of DCIS