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. 2016 Jun 18;158:99–111. doi: 10.1007/s10549-016-3856-2

Fig. 2.

Fig. 2

Human epidermal growth factor receptor 2 (HER2) intratumoral heterogeneity of HER2 negative breast cancer revealed by the HER2 gene-protein assay. a Breast cancer cells showing no HER2 protein expression and nonheterogeneous HER2 gene status. b Breast cancer cells showing no HER2 protein expression and heterogeneous HER2 gene status. Yellow dotted circles show tumor cells with amplified HER2 gene. Black dots and red dots in the nuclei are HER2 gene and chromosome 17 centromere, respectively