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. 2016 Jul 8;36(4):e00356. doi: 10.1042/BSR20160131

Table 1. Characteristics of studies on selenium levels and oesophageal adenocarcinoma risk.

Age (years)
First author (year) Study design Country Participants (cases) Case Control Category (μg/day) RR (95% CI) Adjustment for covariates
Murphy et al. (2010) Case-control United Kingdom 480 (224) 64±11 63±13 <5353–72≥72 11.26 (0.75–2.11)1.20 (0.72–2.00) Adjusted for age, sex, body mass index, energy intake, smoking status, education, occupation, alcohol, regular nonsteroidal antiinflammatory drug (NSAID) use and Helicobacter pylori infection
Ibiebele et al. (2013) Case-control Australia 857 (288) 64±10 58±11 9–3737–4444–5253–165 11.08 (0.74–1.59)0.93 (0.62–1.38)1.15 (0.76–1.73) Adjusted for gender, age, education, body mass index (BMI), oesophageal reflux symptoms, lifetime alcoholic drink, total pack-years of smoking, NSAID use, supplement use and total energy
Steevens et al. (2010) Cohort Netherland 7584 (64) 55–69 55–69 ≤49.849.9–55.255.3–61.3>61.3 11.13 (0.67–1.91)0.84 (0.48–1.49)0.76 (0.41–1.40) Adjusted for age, sex, cigarette smoking, frequency and duration, alcohol consumption and body mass index
O'Rorke et al. (2012) Case-control United Kingdom 341 (125) 64±10.3 63.6±12.7 ≤61.461.5–74.6>74.6 11.03 (0.58–1.76)1.06 (0.49–2.27) Adjusted for age at interview, sex and smoking status (current, former and never)
Takata et al. (2012) Cohort U.S.A. 361 (47) 64.2±10.6 61.1±11.7 <126.3 (μg/l)126.3–143.8>143.8 11.67 (0.79–3.53)1.40 (0.65–3.02) Adjusted for age at time of blood draw, waist:hip ratio (quartiles) at baseline, sex, smoking status and NSAID use