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. 2016 Jun 16;5(6):e002860. doi: 10.1161/JAHA.115.002860

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Apolipoprotein B100 (ApoB100) (low‐density lipoprotein) deposition. A, Representative image (×200) of an aorta with adaptive intimal thickening stained for ApoB100 with a high‐resolution image at a ×400 magnification. ApoB100 accumulation is confined to the intima (black arrow). B, Representative image (×50) of an intimal xanthoma stained for ApoB100 with a high‐resolution image at a ×200 magnification. Increase in intimal ApoB100 deposition within the intima. Accumulation of ApoB100 is restricted to the intima (dotted arrows represent the internal elastic lamina). C, Representative image (×20) of a late fibroatheroma stained for ApoB100 with a high‐resolution image at a ×200 magnification at the intimal‐medial border. This stage of atherosclerosis is characterized by accumulation of ApoB100 within the media, coinciding with loss of integrity of the internal elastic lamina. All ApoB100 samples were visualized with diaminobenzidine (DAB) and counterstained with hematoxylin.