Table 7.
Independent Model Predictors of Primary and Secondary Outcomes in Full 630 Patient Cohort
| Variable | HR (95% CI) | P Value |
|---|---|---|
| Primary CHD outcomea | ||
| UKPDS (per 10% 10‐year risk) | 1.3 (1.1 to 1.5) | 0.003 |
| Gensini score (HR per quartile) | 3.2 (2.1 to 5.0) | <0.0001 |
| Combined noncoronary vascular outcomes | ||
| UKPDS (per 10% 10‐yr risk) | 1.3 (1.2 to 1.4) | <0.0001 |
| Retinopathy at study entry | 3.7 (2.5 to 5.7) | <0.0001 |
| Albuminuria (per 10 mg/mmol creatinine) | 1.3 (1.0 to 1.6) | 0.063 |
| Prior CVA/TIA | 1.8 (0.94 to 3.5) | 0.075 |
| Macrovascular‐related outcomes | ||
| UKPDS (per 10% 10‐yr risk) | 1.3 (1.1 to 1.5) | 0.001 |
| Gensini CAD score (per quartile) | 2.1 (1.7 to 2.9) | <0.0001 |
| Prior CVA/TIA | 2.1 (1.1 to 4.2) | 0.03 |
| Microvascular‐related outcomes | ||
| UKPDS (per 10% 10‐yr risk) | 1.3 (1.2 to 1.5) | 0.0001 |
| Retinopathy at study entry | 5.4 (3.2 to 9.0) | <0.0001 |
| Albuminuria (per 100 μg/mg creatinine) | 1.04 (1.0 to 1.1) | 0.017 |
CAD indicates coronary artery disease; CHD, coronary heart disease; CVA, cerebrovascular accident; HR, hazard ratio; TIA, transient ischemic attack; UKPDS, United Kingdom Prospective Diabetes Study.
a
Maximal plaque burden (HR 17.7 (2.4–131.8), P=0.005) was retained in the model when the Gensini score was entered as a continuous variable but was excluded from the model when the Gensini score was entered as quartiles.