Table 5.

Robustness of the Sex‐Specific Associations Between LTPA Status^a and Cardio‐Metabolic Measures With Respect to an Alternative Definition of Physical Inactivity (LTPA‐Related EE ≥1000 kcal/wk)^b

Cardio‐Metabolic Variables	Women (N=1183 Active and 4569 Inactive)			Men (N=1387 Active and 3446 Inactive)
	OR/βc	95% CI	P Value	OR/β	95% CI	P Value
SBP, mm Hg	−0.70	−1.61 to 0.22	0.14	−0.70	−1.59 to 0.19	0.12
DBP, mm Hg	−0.50	−1.08 to 0.09	0.10	−1.54	−2.13 to −0.95	<0.0001
Heart rate, bpm	−1.54	−2.13 to −0.94	<0.0001	−3.67	−4.28 to −3.06	<0.0001
FHS CVD score	−0.17	−0.45 to 0.11	0.23	−0.53	−0.83 to −0.23	0.001
ASCVD score	−0.04	−0.25 to 0.17	0.71	−0.27	−0.59 to 0.05	0.10
Hypertension	0.85	0.73 to 0.99	0.03	0.85	0.74 to 0.97	0.01
Diabetesd	0.92	0.75 to 1.11	0.38	0.86	0.74 to 1.01	0.07
FHS 10‐yr risk of CVD	0.87	0.74 to 1.02	0.09	0.87	0.78 to 0.98	0.02
10‐yr risk of ASCVD	0.90	0.71 to 1.13	0.35	0.82	0.69 to 0.98	0.02

AHA indicates American Heart Association; ASCVD, arteriosclerotic cardiovascular disease; BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; FHS, Framingham Heart Study; LTPA, leisure time physical activity; SBP, systolic blood pressure.

^aLTPA‐related energy expenditure (LTPA‐EE) ≥1000 kcal/wk vs <1000 kcal/wk.

^bEstimates and 95% CIs were from regular logistic regression or ordered logistic regression or generalized linear regression models adjusting for age, race, study centers, BMI, smoking status, and alcohol consumption.

^cORs are reported to discrete outcomes, and mean differences (βs) were reported for continuous outcomes. For CVD risk scores, ORs comparing the high‐risk category vs the low‐risk category were obtained from ordered logistic regression models.

^dDiabetes was defined using self‐reported information and laboratory measurements (fasting plasma glucose level ≥7.0 mmol/L, 2‐hour postload plasma glucose ≥11.1 mmol/L, or HbA1c ≥6.5%).