Table 6.

Robustness of the Sex‐Specific Associations Between LTPA Status^a and Cardio‐Metabolic Measures With the Effects of Study Centers Treated as Random Effects^b

Cardio‐Metabolic Variables	Women (N=1183 Active and 4569 Inactive)			Men (N=1387 Active and 3446 Inactive)
	OR/βc	95% CI	P Value	OR/β	95% CI	P Value
SBP, mm Hg	−1.35	−2.31 to −0.39	0.006	−1.09	−2.06 to −0.12	0.03
DBP, mm Hg	−0.79	−1.41 to −0.18	0.01	−1.71	−2.35 to −1.07	<0.0001
Heart rate, bpm	−1.96	−2.58 to −1.33	<0.0001	−4.30	−4.96 to −3.64	<0.0001
FHS CVD score	−0.38	−0.67 to −0.09	0.01	−0.84	−1.17 to −0.51	<0.0001
ASCVD score	−0.17	−0.39 to 0.05	0.12	−0.26	−0.62 to 0.08	0.14
Hypertension	0.78	0.66 to 0.92	0.003	0.76	0.65 to 0.88	0.0002
Diabetesd	0.83	0.67 to 1.03	0.09	0.73	0.61 to 0.87	0.0006
FHS 10‐yr risk of CVD	0.77	0.65 to 0.92	0.004	0.67	0.57 to 0.78	<0.0001
10‐yr risk of ASCVD	0.78	0.61 to 1.01	0.06	0.71	0.59 to 0.85	0.0003

AHA indicates American Heart Association; ASCVD, arteriosclerotic cardiovascular disease; BMI, body mass index; CVD, cardiovascular disease; DBP, diastolic blood pressure; FHS, Framingham Heart Study; LTPA, leisure time physical activity; SBP, systolic blood pressure.

^aAHA guidelines recommend at least 150 min/wk moderate exercise or 75 min/wk vigorous exercise.

^bEstimates and 95% CIs were from generalized linear mixed models or cumulative link mixed models or linear mixed models with the effects of study centers treated as random effects, adjusting for age, race, BMI, smoking status, and alcohol consumption.

^cOdds ratios are reported to discrete outcomes, and mean differences (βs) were reported for continuous outcomes. For CVD risk scores, ORs comparing the high‐risk category vs the low‐risk category were obtained from cumulative link mixed models.

^dDiabetes was defined using self‐reported information and laboratory measurements (fasting plasma glucose level ≥7.0 mmol/L, 2‐hour postload plasma glucose ≥11.1 mmol/L, or HbA1c ≥6.5%).