Table 1.
Characteristics of the Multicenter AIDS Cohort Study (MACS) Participants Undergoing Cardiac CT Scana
| HIV‐Infected (N=575) | HIV‐Uninfected (N=348) | P Value | |
|---|---|---|---|
| Age, y | 52.7 (6.6) | 55.4 (7.2) | <0.001 |
| Race | |||
| White (%) | 52.9 | 67.2 | <0.001 |
| African American (%) | 34.1 | 24.4 | |
| Hispanic/other (%) | 13.0 | 8.3 | |
| Hypertension (%) | 49.0 | 43.7 | 0.13 |
| Systolic blood pressure, mm Hg | 126.6 (15.4) | 127.9 (14.6) | 0.22 |
| Hypertension medications (%) | 35.0 | 31.7 | 0.30 |
| Diabetes (%) | 14.8 | 10.5 | 0.08 |
| Diabetes medications (%) | 8.7 | 8.1 | 0.77 |
| Tobacco use | |||
| Never smoker (%) | 24.7 | 25.5 | 0.002 |
| Current smoker (%) | 31.5 | 21.2 | |
| Former smoker (%) | 43.8 | 53.3 | |
| Smoking pack‐yearsb | 6.5 (0–24.0) | 0.7 (0–20.1) | 0.003b |
| Body mass index, kg/m2 | 26.0 (4.5) | 27.4 (5.0) | <0.001 |
| Total cholesterol, mg/dL | 186.6 (43.1) | 192.5 (35.9) | 0.03 |
| LDL cholesterol, mg/dL | 105.8 (36.1) | 114.7 (31.7) | <0.001 |
| HDL cholesterol, mg/dL | 48.6 (16.2) | 53.7 (15.3) | <0.001 |
| Triglycerides, mg/dL | 175.5 (202.0) | 122.2 (66.2) | <0.001 |
| Lipid‐lowering medications (%) | 33.9 | 31.2 | 0.39 |
| Serum creatinine, mg/dL | 1.1 (0.5) | 1.0 (0.2) | 0.01 |
| AHA/ACC 2013 risk score (%) | 8.2 (4.5–12.4) | 8.5 (4.5–12.5) | 0.44b |
| AHA/ACC 2013 risk category | 0.51 | ||
| <5% risk (%) | 30.4 | 26.3 | |
| 5% to 7.4% risk (%) | 15.9 | 18.6 | |
| ≥7.5% (%) | 53.7 | 55.1 | |
| HIV clinical factors | |||
| Current HIV RNA undetectable (<50 copies/mL) (%) | 82.6 | ||
| Current HIV RNA among detectable patients, copies/mL | 842 (139–23 300)b | ||
| Current CD4+ T‐cell count, cells/mm3 | 698 (499–936)b | ||
| CD4+ T‐cell count nadir, cells/mm3 | 367 (242–557)b | ||
| HAART experienced (%) | 96.0 | ||
| Protease inhibitor use (%) | 44.8 | ||
| NNRTI use (%) | 46.8 | ||
| HAART duration, y | 9.5 (6.3–12.5)b | ||
| Protease inhibitor duration, y | 4.9 (0.3–9.6)b | ||
| NNRTI duration, y | 4.0 (0.7–8.0)b | ||
ACC indicates American College of Cardiology; AHA, American Heart Association; CT, computed tomography; HAART, highly active antiretroviral treatment; HDL, high‐density lipoprotein cholesterol; LDL, low‐density lipoprotein cholesterol; NNRTI, non‐nucleoside reverse transcriptase inhibitor.
a
Mean (SD) is presented for continuous variables with normal distribution and percentage for categorical variables.
b
Median (interquartile range) presented because the distribution was not normal. Wilcoxon Rank‐Sum test was used for comparison between groups.