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. 2016 Mar 21;44(12):5646–5657. doi: 10.1093/nar/gkw176

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Dam^{4-HT-intein@L127C}-PC DamID profiles in Drosophila tissues. (A) Comparison of PC DamID profiles in Kc cells, Drosophila larval central brain and fat bodies. A 2.0 Mb fragment of chromosomal arm 2L is shown. Data for Kc cells are from (10). (B and C) Comparison of conventional Dam-PC profile (26) and Dam^{4-HT-intein@L127C}-PC DamID profile, both in larval central brain. (B) Genome-wide correlation between the data sets. r, Pearson's correlation coefficient; n, number of GATC fragments compared. (C) A 1.0 Mb fragment of chromosomal arm 2L is shown. The lower noise level and wider dynamic range of the Dam^{4-HT-intein@L127C}-PC DamID profile might be due to different detection platform used (high-throughput sequencing instead of microarrays). In (A) and (C) a running mean algorithm (a sliding window of 10 GATC fragments, one GATC fragment per step) was applied to the PC binding data; genes are indicated by black rectangles.