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. 2016 May 24;44(12):5849–5860. doi: 10.1093/nar/gkw445

Figure 5.

Figure 5.

Conformational dynamics are modulated by the chemical state of the ATP-binding pocket. The conformational dynamics are significantly reduced upon introducing 2 mM ADP-BeFx (light purple), a non-hydrolyzable ATP analog, in comparison to other nucleotides: 2 mM ADP (light blue), 2 mM ADP and Pi (gray), 2 mM AMP-PNP (light brown) and in the absence of ATP (brown). For comparison, we also show RecBCD bound to blunt-ended DNA (blue) and RecBCD stalled in the middle of the DNA (red). Conditions with asterisks have P < 0.05. Number symbol (#) represents P = 0.13.