Table 2. Overlap between tissue-specific signaling hubs of liver, bone marrow and kidney and genes associated with their tissue-specific anomaly phenotypes. Each row indicates a set of tissue-specific signaling hubs and each column indicates a set of tissue-specific phenotypic genes that were compared with tissue-specific signaling hubs. Statistical significances of overlaps were calculated by hypergeometric tests. Bolded was the most significant among overlaps of tissue-specific signaling hubs to genes associated with tissue-specific phenotypes of liver, bone marrow and kidney.

Tissue-specific signaling hubs	Overlap to liver phenotype genes (493 genes): number (P-value)	Overlap to bone marrow phenotype genes (289 genes): number (P-value)	Overlap to kidney phenotype genes (517 genes): number (P-value)
Liver-specific signaling hubs (98 genes)	8 (0.011)*	3 (0.26)	6 (0.099)
Bone marrow-specific signaling hubs (198 genes)	8 (0.27)	10 (0.0034)**	13 (0.013)*
Kidney-specific signaling hubs (166 genes)	9 (0.074)	5 (0.18)	12 (0.0081)**

*P-value < 0.05.

**P-value < 0.01.