Table 1. Multiple regression analysis of TARDBP mRNA and neuron compartment.

	Standardized regression coefficient		Coefficient of determination (adjusted r2)
	SALS	Neuron area (μm2)
Nuclear TARDBP mRNA	−1.026*	0.001**	0.096**
Cytoplasmic TARDBP mRNA	3.937*	0.006**	0.208**
Total TARDBP mRNA	2.911*	0.007**	0.199**

We performed a stepwise multiple linear regression analysis using the neuron compartment and SALS (sporadic ALS) as independent variables to examine the independent predictors of the number of TARDBP mRNA spots. Correlation coefficients are shown. *P < 0.05, **P < 0.01.