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. 2016 Apr 27;128(1):e1–e9. doi: 10.1182/blood-2015-11-683334

Figure 2.

Figure 2

Genomic characterization of myeloid malignancies using Karyogene. Individual AML (n = 62) and MDS (n = 50) samples are represented in columns and genetic mutations in rows. AML samples were unselected whereas MDS samples were pre-selected to harbor chromosomal copy number changes. Mutations are grouped into chromosomal translocations (top), substitutions and indels (middle), CNAs (bottom), and CN-LOH events (bottom row). Clinically relevant CNAs are depicted in separate rows and “other large CNAs” refers to changes affecting regions larger than 3 mbp (described in detail in supplemental Figure 3). The presence of mutations in different contexts is indicated according to the key (bottom left). TF, transcription factor.