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. 2016 Jul 8;6:29094. doi: 10.1038/srep29094

Figure 5. Sweet receptors and Gα14 in hypothalamic neurons are regulated by glucose and leptin levels.

Figure 5

(A) Sweet taste receptor subunits and GPCTRs α subunit mRNA expression in a hypothalamic neuronal cell line after one hour incubation of high glucose levels. T1R2 and Gα14 were downregulated after incubation with high glucose. Glucose Treatment, p = 0.004; Gene, p = 0.587; Interaction, p = 0.220. (B) Sweet taste receptor subunits and GPCTRs α subunit mRNA expression in a hypothalamic neuronal cell line after 7 hour incubation of high glucose levels. T1R2 was downregulated after incubation with high glucose. Glucose treatment, p = 0.011; Gene, p = 0.494; Interaction, p = 0.158. (C) Sweet taste receptor subunits and GPCTRs α subunit mRNA expression in a hypothalamic neuronal cell line after one hour incubation high leptin concentrations. T1R2 and T1R3 were downregulated after incubation with high leptin. Leptin treatment, p = 0.019; Gene, p = 0.804; Interaction, p = 0.909. (D) Sweet taste receptor subunits and GPCTRs α subunit mRNA expression in a hypothalamic neuronal cell line after 7 hour incubation high leptin concentrations. No significant changes in expression following high leptin. Leptin treatment, p = 0.119; Gene, p = 0.548; Interaction, p = 0.931.