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. 2016 Jul 8;6:29094. doi: 10.1038/srep29094

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Sweet and bitter taste receptor mRNA expression in tongue of ad libitum wild type and obese (ob/ob and DIO) mice. DIO animals showed reduced T1R2 and T2R118 expression. (B) GPCTR signalling pathway mRNA expression in tongue of ad libitum wild type and obese (ob/ob and DIO) mice. (C) Sweet and bitter taste receptor mRNA expression in duodenum of ad libitum wild type and obese (ob/ob and DIO) mice. T1R3 and T1R2 were downregulated in ob/ob and DIO animals. T2R116, T2R118, T2R104 showed a downregulation only in DIO animals. (D) GPCTR signalling pathway mRNA expression in duodenum of ad libitum wild type and obese (ob/ob and DIO) mice. αTransd was downregulated in obese (ob/ob and DIO) animals, TRPM5 was downregulated in DIO animals. (E) Sweet and bitter taste receptor mRNA expression in trachea of ad libitum wild type and obese (ob/ob and DIO) mice. T2R118 was decreased in DIO animals. (F) GPCTR signalling pathway mRNA expression in trachea of ad libitum wild type and obese (ob/ob and DIO) mice. (G) Sweet and bitter taste receptor mRNA expression in lungs of ad libitum wild type and obese (ob/ob and DIO) mice. T1R3 was upregulated in DIO mice. (H) GPCTR signalling pathway mRNA expression in lungs of ad libitum wild type and obese (ob/ob and DIO) mice. Gα14 was downregulated in obese (ob/ob and DIO) animals. PLCβ2 was upregulated in DIO animals. (I) Sweet and bitter taste receptor mRNA expression in liver of ad libitum wild type and obese (ob/ob and DIO) mice. T1R3 and T1R2 were upregulated in DIO animals, T2R138 was upregulated in ob/ob and DIO animals. J) GPCTR signalling pathway mRNA expression in liver of ad libitum wild type and obese (ob/ob and DIO) mice. Gα14 was upregulated in DIO mice, αTransd was upregulated in ob/ob and DIO mice.