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. 2016 Jul 8;6:29446. doi: 10.1038/srep29446

Figure 1.

Figure 1

Representative recordings of (A), MEPP and (B), EPP responses during control and HT treated conditions. Sample recordings are ten consecutive responses from control and HT12 (10 mM) conditions. (C), dose response curves for HT1 (n = 4), HT3 (n = 3) and HT12 (n = 3). Normalised end-plate potential amplitudes (±SEM) were recorded at each concentration for individual HT peptides; HT1 (filled squares), HT3 (open triangles), and HT12 (open circles). Each peptide elicited a similar dose-dependent decrease in EPP amplitude, with no significant difference observed between peptides (P > 0.05). (D) dose dependent decrease in EPP amplitude in the presence of native tick saliva (0.7 mg/mL). Significance indicated is in relation to control values for respective HTs; HT1 *P < 0.05 and ***P < 0.001, for HT3 ♦P < 0.05, ♦♦P < 0.01 and ♦♦♦P < 0.001, for HT12 #P < 0.05, ##P < 0.01, for saliva *P < 0.05 and **P < 0.01 (One-way ANOVA with Bonferonni post test).