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. 2016 May 18;203(3):1177–1190. doi: 10.1534/genetics.116.188797

Figure 1.

Figure 1

Cartoon of cis- and trans-regulation. A1 and A2 are alleles from two different testcrosses of a parental line (A1, red; A2, cross-hatched red) with a tester allele (At, blue). Alleles are tracked by SNPs within the coding sequence. Note that these SNPs are not necessarily causal. For testcross 1, there is no allelic imbalance; allele-specific expression is equal between the A1 allele and the At allele. For testcross 2, the A2 allele is different from the At allele, indicating cis-regulation. In this cartoon, the expression of the exon is regulated by a regulatory SNP within the gene’s promoter. Trans-effects are identified by comparing the expression of the At allele in testcross 1 to the expression of the At allele in testcross 2.