. 2016 May 2;203(3):1315–1334. doi: 10.1534/genetics.116.188912

Table 3. Simulation and theoretical results for a single locus with heterozygote advantage.

Generation 0.5N				Generation 2N
2N $\tilde{s}$	2N $\tilde{t}$	H_rel	P_s	2N $\tilde{s}$	2N $\tilde{t}$	H_rel	P_s
2Ns = 0.2, 2Nt = 0.2, q* = 0.5, N = 50, x₀ = 0.1
C = 0
0.094 (0.00004)	0.019 (0.00001)	1.0002 (0.0004)	0.5533 (0.0002)	0.105 (0.00009)	0.077 (0.00008)	1.0082 (0.0007)	0.1966 (0.0001)
0.258^a	0.046^a	1.0003^a	0.5536 (0.0002)^b	0.212^a	0.108^a	1.0083^a	0.1956 (0.0001)^b
C = 0.1
0.092 (0.00004)	0.020 (0.00001)	1.0005 (0.0004)	0.5535 (0.0002)	0.096 (0.00008)	0.070 (0.00007)	1.0311 (0.0007)	0.1964 (0.0001)
0.251^a	0.043^a	1.0003^a		0.179^a	0.092^a	1.0078^a
C = 1
0.079 (0.00004)	0.016 (0.00001)	1.0008 (0.0004)	0.5533 (0.0002)	0.071 (0.00006)	0.035 (0.00005)	1.0053 (0.0007)	0.1962 (0.0001)
0.210^a	0.037^a	1.0003^a		0.103^a	0.061^a	1.0046^a
C = 10
0.032 (0.00002)	0.005 (0.00001)	1.0004 (0.0004)	0.5532 (0.0002)	0.008 (0.00002)	0.005 (0.00001)	1.0004 (0.0007)	0.1956 (0.0001)
0.056^a	0.011^a	1.0001^a		0.016^a	0.008^a	1.0004^a
2Ns = 0.2, 2Nt = 0.1, q* = 0.667, N = 50, x₀ = 0.1
C = 0
0.062 (0.00003)	0.013 (0.00001)	1.0023 (0.0004)	0.5534 (0.0002)	0.069 (0.00006)	0.051 (0.00006)	1.0056 (0.0007)	0.1962 (0.0001)
0.171^a	0.031^a	1.0002^a	0.5536 (0.0002)^b	0.137^a	0.070^a	1.0054^a	0.1956 (0.0001)^b
C = 0.1
0.061 (0.00003)	0.013 (0.00001)	1.0024 (0.0004)	0.5531 (0.0002)	0.063 (0.00006)	0.046 (0.00005)	1.0198 (0.0007)	0.1961 (0.0001)
0.171^a	0.032^a	1.0002^a		0.178^a	0.091^a	1.0051^a
C = 1
0.053 (0.00003)	0.010 (0.00001)	1.0010 (0.0004)	0.5532 (0.0002)	0.033 (0.00004)	0.023 (0.00003)	1.0021 (0.0007)	0.1959 (0.0001)
0.137^a	0.025^a	1.0002^c		0.070^a	0.035^a	1.0030^a
C = 10
0.021 (0.00001)	0.003 (0.00001)	1.0000 (0.0004)	0.5531 (0.0002)	0.006 (0.00001)	0.003 (0.00001)	0.9997 (0.0007)	0.1953 (0.0001)
0.035^a	0.006^a	1.0001^c		0.010^a	0.005^a	1.0002^a

Standard errors for 10⁷ simulations are in parentheses, following the corresponding means.

Approximate values of r² were obtained from the matrix recursions; neutral values were used for the expectations of x^–1 and (1 – x) ^–1 (Equation A11 and following text); the linear approximation was used for the heterozygosity at locus B (Equation A3).

Values from neutral simulations.